In 2000, I developed the KHU-PIPE system as a comprehensive oriental medical decision-making support system by applying a rule-based reasoning method to a standardized knowledge base. And 2002 I developed OMS-Prime system. Recently, PIPE-11 (Pattern Identification and Prescription Expert on the ICD_11) that include ICD-11 was completed. That system is significantly revising OMS-Prime developed in 2002.